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CURB-65 (Clinical Prediction Rule)


CURB-65 Basic Facts:
  • CURB-65 (CURB criteria) is a clinical prediction rule.
  • It is an acronym for 5 risk factors (each scoring one point) giving a maximum score of 5.
  • Validated for predicting mortality in community-acquired pneumonia (Lim et al 2003). [1]
  • More recently the CURB-65 has been validated for mortality prediction for infections at any site (Howell et al 2007). [2]
CURB-65 Acronym:
  • C - Confusion (defined as an AMT(*) of 8 or less).
  • U - Urea greater than 7 mmol/l (Blood Urea Nitrogen > 19).
  • R - Respiratory rate of 30 breaths per minute or more.
  • B - Blood pressure (BP) less than 90 mmHg systolic or diastolic BP 60 mmHg or less.
  • 65 - Age 65 or older.
CURB-65 Score Mortality Prediction (Pneumonia):
  • 0 = 0.7%
  • 1 = 3.2%
  • 2 = 13.0%
  • 3 = 17.0%
  • 4 = 41.5%
  • 5 = 57.0%
CURB-65 Score Mortality Prediction (Any Infection):
  • 0 to 1 = < 5% mortality.
  • 2 to 3 = < 10% mortality.
  • 4 to 5 = 15-30% mortality.
(*) AMT = Abbreviated Mental Test Score

References:

[1] - Lim WS, van der Eerden MM, Laing R, et al. (2003). "Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study". Thorax 58 (5): 377–82.
[2] - Howell MD, Donnino MW, Talmor D, Clardy P, Ngo L, Shapiro NI (2007). "Performance of severity of illness scoring systems in emergency department patients with infection". Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 14 (8): 709–14.


Image - Lobar Pneumonia Pathology by Pulmonary Pathology (cc)

Posted by ALCHEssMIST.
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